A Genetic Test to End Angiography?: A Best Evidence Interview With Eric J. Topol, MD

A Best Evidence Interview With Eric J. Topol, MD

The Best Evidence Study

Dr. Topol is senior author of:

Rosenberg S, Elashoff MR, Beineke B, et al; PREDICT (Personalized Risk Evaluation and Diagnosis in the Coronary Tree) Investigators. Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Ann Intern Med. 2010;153:425-434.

About the Interviewee

Eric J. Topol, MD, is the Director of the Scripps Translational Science Institute, a National Institutes of Health-funded program of the Clinical and Translational Science Award (CTSA) Consortium. In 2009, he was named the Gary and Mary West Endowed Chair of Innovative Medicine. He is Professor of Translational Genomics at The Scripps Research Institute, the Chief Academic Officer of Scripps Health, and a senior consultant cardiologist practitioner at Scripps Clinic. Prior to coming to Scripps, he served on the faculty of Case Western as a professor in genetics, chaired the Department of Cardiovascular Medicine at Cleveland Clinic for 15 years and raised its status to rank #1 by US News and World Report for 11 consecutive years, and founded the Cleveland Clinic Lerner College of Medicine. His work in the genomics of heart attack has led to discovery of key genes (MEF2A deletion, THSB-4 variant), which led to recognition by the American Heart Association as top 10 research advances in 2002 and 2004. As a leader in clinical trials of novel therapeutics, he administered recombinant tPA to the first patient in 1984 and pioneered and led the clinical development of clopidogrel (Plavix), bivalirudin (Angiomax), and abciximab (ReoPro). He has over 1000 original peer-reviewed publications and has edited over 30 books, including the Textbook of Interventional Cardiology (5th ed), and the Textbook of Cardiovascular Medicine (3rd ed). Dr. Topol is also Editor-in-Chief of Medscape's Genomic Medicine Resource Center (http://medscape.com/resource/genomic-medicine).