Today: 4D Multimodal Nanomedicines Made of Non-Equilibrium Au-Fe Alloy Nanoparticles, Sep 08, 2020

Sep 8, 2020

4D Multimodal Nanomedicines Made of Non-Equilibrium Au-Fe Alloy Nanoparticles, Sep 08, 2020

Go to Volume 0, Issue ja

Abstract

Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of nano-agents that can be removed from the body after use remains thus a great challenge. Here, we demonstrate that non-equilibrium gold-iron alloys behave as shape-morphing nanocrystals with the properties of self-degradable multifunctional nanomedicines. DFT calculations combined with mixing enthalpy-weighted alloying simulations predict that Au-Fe solid solutions can exhibit self-degradation in aqueous environment if the Fe content exceeds a threshold that depends upon element topology in the nanocrystals. Exploiting a laser-assisted synthesis route, we experimentally confirm that non-equilibrium Au-Fe nanoalloys have a 4D behavior, that is the ability to change shape, size and structure over time, becoming ultrasmall Au-rich nanocrystals. In vivo tests
show the potential of these transformable Au-Fe nanoalloys as efficient multimodal contrast agents for magnetic resonance imaging and computed x-ray absorption tomography and further demonstrate their self-degradation over time, with a significant reduction of long-term accumulation in the body, when compared to benchmark gold or iron oxide contrast agents. Hence, Au-Fe alloy nanoparticles exhibiting 4D behavior can respond to the need for safe and degradable inorganic multifunctional nanomedicines required in clinical translation.
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